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pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Might lead to loss of virologic reaction and achievable resistance.pentobarbital will reduce the level or effect of almotriptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Us